How does taking STIVARGA fit into my daily routine?

STIVARGA is a once-daily oral therapy that can be stored at room temperature between 68° F to 77° F.

STIVARGA should be swallowed whole with water and after a low-fat meal. This is a meal that contains less than 600 calories and less than 30% fat.

You can decide what time you want to take STIVARGA each day. You may prefer to take it with breakfast, dinner, or a midday meal. The important thing is to be consistent and take STIVARGA at the same time each day.

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What to Avoid

You should avoid consuming grapefruit juice and St. John's Wort during treatment with STIVARGA, as these may affect the way the medicine works.

Tips for Meal-planning

Explore some examples of good, low-fat meal choices below:

    • 1% low-fat cottage cheese (4 ounces)
    • English muffin (1)
    • Fat-free butter (1 tablespoon)
    • Jam or preserves (1 tablespoon)
    • Apple juice (8 ounces)
    Total calories: 379 | Total fat: 5.9%
    • Turkey breast lunch meat (2 slices)
    • Toasted white bread (2 slices)
    • Real mayonnaise (1 tablespoon)
    • Lettuce and tomato (1 leaf/slice)
    • 1 large apple (3 & 1/4")
    • Cranberry juice (8 ounces)
    Total calories: 496 | Total fat: 23.6%
    • Spaghetti cooked without added salt (1 cup)
    • Spaghetti marinara (meatless) sauce (1/2 cup)
    • Salad, vegetables (1 & 1/2 cups)
    • Salad dressing (oil and vinegar) (1 tablespoon)
    Total calories: 435 | Total fat: 26.5%

    How long will I be taking STIVARGA?

    The recommended dose of STIVARGA is 160 mg (four 40-mg tablets) every day for 3 weeks, followed by a 1-week break. This is 1 cycle of treatment. Your doctor may stop your treatment or change the dose. Be sure to take the dose based on the schedule that your doctor prescribes for you. Continue taking STIVARGA until your healthcare provider tells you to stop.


    Tips When Starting STIVARGA

    Contact your doctor’s office as soon as you first receive STIVARGA to schedule your first appointment within the week.

    • If you experience side effects, it's important to let your doctor or another member of your treatment team know right away, even if you feel it is minor.

    Here is an example of what a daily dosing schedule could look like:

    Daily Dosing Schedule

    Dosing schedule chart

    Be sure you understand the daily dose (number of tablets each day) that your doctor has prescribed for you and follow the directions for treatment.

    • If you miss a dose, take it as soon as you remember on that day
    • If you forget to take STIVARGA until the next day, NEVER try to “catch up”—don’t take 2 doses on the same day to make up for a missed dose
    • Call your healthcare provider or go to the nearest emergency room right away if you take more than your prescribed dose by mistake

      What should I tell my doctor or nurse before taking STIVARGA?

      Before taking STIVARGA, tell your healthcare provider about all of your medical conditions, including if you:

      • have liver problems in addition to liver cancer
      • have bleeding problems
      • have high blood pressure
      • have heart problems or chest pain
      • plan to have surgery or have had a recent surgery. You should stop taking STIVARGA at least 2 weeks before planned surgery
      • are pregnant or plan to become pregnant. STIVARGA can harm your unborn baby. Females and males with female partners who can become pregnant should use effective birth control during treatment with STIVARGA and for 2 months after their last dose of STIVARGA. Tell your healthcare provider right away if you or your partner becomes pregnant either while taking STIVARGA or within 2 months after your last dose of STIVARGA
      • are breastfeeding or plan to breastfeed. It is not known if STIVARGA passes into your breast milk. Do not breastfeed during treatment with STIVARGA and for 2 weeks after your final dose of STIVARGA

      Tell your doctor or nurse about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. STIVARGA may affect the way other medicines work, and other medicines may affect how STIVARGA works.


      Know Your Medicines

      Know the medicines you take. Keep a list of your medicines and show it to your healthcare provider when you get a new medicine.

      STIVARGA can be kept at room temperature between 68° F to 77° F.

      Here are some “dos” and “don'ts” for proper storage of STIVARGA:


      • Always keep STIVARGA tightly closed in its original bottle as it contains a special drying agent (called a desiccant) to keep your medicine dry
      • Remove the drying agent to get tablets from the bottle. Always put it back in the bottle after getting your medicine
      • Always keep the bottle of STIVARGA tightly closed and store at room temperature (68°-77° F) in cases where the weather can fluctuate above or below the range
      • Only open 1 bottle of STIVARGA at a time
      • Keep STIVARGA and all medicines out of the reach of children
      STIVARGA® (regorafenib) pill bottle. Visit to see full Safety and Prescribing Information, including Boxed Warning.

      • Use STIVARGA tablets after the bottle has been opened for 7 weeks or more. These tablets should be safely thrown away
      • Put the tablets in a pillbox; keep STIVARGA in the original bottle with the drying agent