IMPORTANT SAFETY INFORMATION: STIVARGA can cause liver problems, which can be serious and sometimes lead to death. Your healthcare provider will do blood tests... Continue reading below
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Understanding side effects with STIVARGA® (regorafenib)

When you’re considering another medication, understanding the side effects is just as important as understanding the benefits. Make sure you talk to your doctor about what to watch for and refer to your starter kit for tips and additional information.

Tips for your experience on STIVARGA
  • Side effects may occur early in treatment. It's important to let your doctor or another member of your treatment team know right away, even if you feel it is minor
  • Your doctor may adjust your dose of STIVARGA, temporarily stop treatment, or permanently discontinue treatment. Sometimes your doctor may stop treatment entirely

Possible side effects
Common side effects
Considerations for hand-foot skin reaction
Considerations for tiredness
Considerations for diarrhea

Diarrhea: What you can do

STIVARGA may cause diarrhea. If you get diarrhea, tell your healthcare provider right away. You might need treatment to replace important fluids in your body or to keep you from losing too much weight.

Following these tips can help treat diarrhea:

  • Eat several small meals each day, instead of 2 or 3 large ones
    • Try bland foods, like bananas, rice, applesauce, and toast
  • Drink plenty of water, but stay away from hot or iced drinks
  • Stay away from spicy foods, dairy products, caffeine, and alcohol
  • Take diarrhea medicine as directed by your healthcare provider

Be alert

Talk to your healthcare provider about any side effects you are having


STIVARGA (regorafenib) is a prescription medicine used to treat people with:

It is not known if STIVARGA is safe and effective in children less than 18 years of age.

Important Safety Information

STIVARGA (regorafenib) can cause liver problems, which can be serious and sometimes lead to death. Your healthcare provider will do blood tests to check your liver function before you start taking STIVARGA and during your treatment with STIVARGA to check for liver problems. Tell your healthcare provider right away if you experience yellowing of your skin or the white part of your eyes, nausea, vomiting, dark urine, or change in your sleep pattern.

Before taking STIVARGA, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the prescription and over-the-counter medicines, vitamins, and herbal supplements you take. Avoid drinking grapefruit juice and taking St. John’s Wort while taking STIVARGA.

STIVARGA may cause serious side effects, including:

The most common side effects with STIVARGA include pain including stomach-area (abdomen); tiredness, weakness, fatigue; diarrhea (frequent or loose bowel movements); decreased appetite; infection; voice change or hoarseness; increase in certain liver function tests; fever; swelling, pain, and redness of the lining in your mouth, throat, stomach, and bowel (mucositis); and weight loss.

For important risk and use information about STIVARGA, please see the full Prescribing Information, including Boxed Warning.

You are encouraged to report negative side effects or quality complaints of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.