IMPORTANT SAFETY INFORMATION: STIVARGA can cause liver problems, which can be serious and sometimes lead to death. Your healthcare provider will do blood tests... Continue reading below
Bayer logo

Understanding side effects with STIVARGA® (regorafenib)

When you’re considering another medication, understanding the side effects is just as important as understanding the benefits. Make sure you talk to your doctor about what to watch for and refer to your starter kit for tips and additional information.


Tips for your experience on STIVARGA
  • Side effects may occur early in treatment. It's important to let your doctor or another member of your treatment team know right away, even if you feel it is minor
  • Your doctor may adjust your dose of STIVARGA, temporarily stop treatment, or permanently discontinue treatment. Sometimes your doctor may stop treatment entirely

Possible side effects
Blue caret
Common side effects
Blue caret
Considerations for hand-foot skin reaction
Blue caret
Considerations for tiredness
Blue caret
Considerations for diarrhea
Blue caret

Most common side effects

People in the clinical trials experienced side effects when taking STIVARGA. Side effects with STIVARGA may occur early on in treatment.

In clinical trials, the most common side effects with STIVARGA included:

tiredness, weakness, fatigue
frequent or loose bowel movements (diarrhea)
loss of appetite
swelling, pain, and redness of the lining of your mouth, throat, stomach, and bowel (mucositis)
voice changes or hoarseness
infection
pain in other parts of your body
weight loss
nausea
abdomen (stomach-area) pain
fever

Stay in Tune

You know your body best! So be on the lookout for side effects. Tell your doctor or nurse about any side effect that bothers you or does not go away.


Treatment balance

The goal of therapy with STIVARGA is to balance potential treatment benefit with potential side effects.

That’s why it is important to communicate with your treatment team. Your doctor may change your dose, temporarily stop, or permanently stop STIVARGA if you have certain side effects. Your doctor will decide which treatment changes are right for you.

Your treatment team

Indications

STIVARGA® (regorafenib) is a prescription medicine used to treat people with:

It is not known if STIVARGA is safe and effective in children less than 18 years of age

Important Safety Information

STIVARGA can cause liver problems which can be serious and sometimes lead to death. Your healthcare provider will do blood tests to check your liver function before you start taking STIVARGA and during your treatment with STIVARGA to check for liver problems. Tell your healthcare provider right away if you experience yellowing of your skin or the white part of your eyes, nausea, vomiting, dark urine, or changes in your sleep pattern.

Before taking STIVARGA, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the prescription and over-the-counter medicines, vitamins, and herbal supplements you take. Avoid drinking grapefruit juice and taking St. John's Wort during treatment with STIVARGA.

STIVARGA may cause serious side effects, including:

The most common side effects with STIVARGA include tiredness, weakness, fatigue; diarrhea (frequent or loose bowel movements); loss of appetite; swelling, pain, and redness of the lining in your mouth, throat, stomach, and bowel (mucositis); voice changes or hoarseness; infection; pain in other parts of your body; weight loss; abdomen (stomach-area) pain; fever; and nausea.

These are not all of the possible side effects of STIVARGA. For more information, ask your healthcare provider or pharmacist.

Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with STIVARGA if you have certain side effects.

Tell your doctor if you have any side effects that bother you or that do not go away.

For important risk and use information about STIVARGA, please see the full Prescribing Information, including Boxed Warning.

You are encouraged to report negative side effects or quality complaints of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.