IMPORTANT SAFETY INFORMATION: STIVARGA can cause liver problems, which can be serious and sometimes lead to death. Your healthcare provider will do blood tests... Continue reading below
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Understanding side effects with STIVARGA® (regorafenib)

When you’re considering another medication, understanding the side effects is just as important as understanding the benefits. Make sure you talk to your doctor about what to watch for and refer to your starter kit for tips and additional information.


Tips for your experience on STIVARGA
  • Side effects may occur early in treatment. It's important to let your doctor or another member of your treatment team know right away, even if you feel it is minor
  • Your doctor may adjust your dose of STIVARGA, temporarily stop treatment, or permanently discontinue treatment. Sometimes your doctor may stop treatment entirely

Possible side effects
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Common side effects
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Considerations for hand-foot skin reaction
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Considerations for tiredness
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Considerations for diarrhea
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Most common side effects

People in the clinical trials experienced side effects when taking STIVARGA. Side effects with STIVARGA may occur early on in treatment.

In clinical trials, the most common side effects with STIVARGA included:

stomach-area (abdomen) pain
tiredness, weakness, fatigue
diarrhea (frequent or loose bowel movements)
decreased appetite
infection
voice change or hoarseness
increase in certain liver function tests
fever
swelling, pain, and redness of the lining in your mouth, throat, stomach, and bowel (mucositis)
weight loss

Stay in Tune

You know your body best! So be on the lookout for side effects. Tell your doctor or nurse about any side effect that bothers you or does not go away.


Treatment balance

The goal of therapy with STIVARGA is to balance potential treatment benefit with potential side effects.

That’s why it is important to communicate with your treatment team. Your doctor may change your dose, temporarily stop, or permanently stop STIVARGA if you have certain side effects. Your doctor will decide which treatment changes are right for you.

Your treatment team

Indications

STIVARGA® (regorafenib) is a prescription medicine used to treat people with:

It is not known if STIVARGA is safe and effective in children less than 18 years of age.

Important Safety Information

STIVARGA (regorafenib) can cause liver problems, which can be serious and sometimes lead to death. Your healthcare provider will do blood tests to check your liver function before you start taking STIVARGA and during your treatment with STIVARGA to check for liver problems. Tell your healthcare provider right away if you experience yellowing of your skin or the white part of your eyes, nausea, vomiting, dark urine, or change in your sleep pattern.

Before taking STIVARGA, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the prescription and over-the-counter medicines, vitamins, and herbal supplements you take. Avoid drinking grapefruit juice and taking St. John’s Wort while taking STIVARGA.

STIVARGA may cause serious side effects, including:

The most common side effects with STIVARGA include pain including stomach-area (abdomen); tiredness, weakness, fatigue; diarrhea (frequent or loose bowel movements); decreased appetite; infection; voice change or hoarseness; increase in certain liver function tests; fever; swelling, pain, and redness of the lining in your mouth, throat, stomach, and bowel (mucositis); and weight loss

For important risk and use information about STIVARGA, please see the full Prescribing Information, including Boxed Warning.

You are encouraged to report negative side effects or quality complaints of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.