STIVARGA is a once-daily oral therapy that can be stored at room temperature between
68° F to 77° F.
STIVARGA should be swallowed whole with water and after a low-fat meal. This is a meal that contains less than 600 calories and less than 30% fat.
You can decide what time you want to take STIVARGA each day. You may prefer to take it with breakfast, dinner, or a midday meal. The important thing is to be consistent and take STIVARGA at the same time each day.
You should avoid consuming grapefruit juice and St. John's Wort during treatment with STIVARGA, as these may affect the way the medicine works.
Explore some examples of good low-fat meal choices below:
The recommended dose of STIVARGA is 160 mg (four 40-mg tablets) every day for 3 weeks, followed by a 1-week break. This is 1 cycle of treatment. Your doctor may stop your treatment or change the dose. Be sure to take the dose based on the schedule that your doctor prescribes for you. Continue taking STIVARGA until your doctor or nurse tells you to stop.
Contact your doctor’s office as soon as you first receive STIVARGA to schedule your first appointment within the week.
Here is an example of what a daily dosing schedule could look like:
Be sure you understand the daily dose (number of tablets each day) that your doctor has prescribed for you and follow the directions for treatment.
See how you can save money on out-of-pocket costs for STIVARGA
Know what to expect from treatment before you get started
Use your Treatment Journal to easily record the daily tablets you have taken and how you are feeling
Connect with financial resources and treatment counseling
STIVARGA® (regorafenib) is a prescription medicine used to treat people with:
It is not known if STIVARGA is safe and effective in children less than 18 years of age.
STIVARGA (regorafenib) can cause liver problems, which can be serious and sometimes lead to death. Your healthcare provider will do blood tests to check your liver function before you start taking STIVARGA and during your treatment with STIVARGA to check for liver problems. Tell your healthcare provider right away if you experience yellowing of your skin or the white part of your eyes, nausea, vomiting, dark urine, or change in your sleep pattern.
Before taking STIVARGA, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the prescription and over-the-counter medicines, vitamins, and herbal supplements you take. Avoid drinking grapefruit juice and taking St. John’s Wort while taking STIVARGA.
STIVARGA may cause serious side effects, including:
The most common side effects with STIVARGA include pain including stomach-area (abdomen); tiredness, weakness, fatigue; diarrhea (frequent or loose bowel movements); decreased appetite; infection; voice change or hoarseness; increase in certain liver function tests; fever; swelling, pain, and redness of the lining in your mouth, throat, stomach, and bowel (mucositis); and weight loss
You are encouraged to report negative side effects or quality complaints of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.