IMPORTANT SAFETY INFORMATION: STIVARGA can cause liver problems, which can be serious and sometimes lead to death. Your healthcare provider will do blood tests... Continue reading below
Bayer logo

Taking STIVARGA® (regorafenib)

How does taking STIVARGA fit into my daily routine?

STIVARGA is a once-daily oral therapy that can be stored at room temperature between
68° F to 77° F.

STIVARGA should be swallowed whole with water and after a low-fat meal. This is a meal that contains less than 600 calories and less than 30% fat.

You can decide what time you want to take STIVARGA each day. You may prefer to take it with breakfast, dinner, or a midday meal. The important thing is to be consistent and take STIVARGA at the same time each day.


What to Avoid

You should avoid consuming grapefruit juice and St. John's Wort during treatment with STIVARGA, as these may affect the way the medicine works.


Tips for Meal-planning

Explore some examples of good low-fat meal choices below:

Breakfast
+
Lunch
+
Dinner
+

How long will I be taking STIVARGA?

The recommended dose of STIVARGA is 160 mg (four 40-mg tablets) every day for 3 weeks, followed by a 1-week break. This is 1 cycle of treatment. Your doctor may stop your treatment or change the dose. Be sure to take the dose based on the schedule that your doctor prescribes for you. Continue taking STIVARGA until your doctor or nurse tells you to stop.


Tips When Starting STIVARGA

Contact your doctor’s office as soon as you first receive STIVARGA to schedule your first appointment within the week.

  • If you experience side effects, it's important to let your doctor or another member of your treatment team know right away, even if you feel it is minor

Here is an example of what a daily dosing schedule could look like:

STIVARGA (regorafenib)  Daily Dosing Schedule chart

Be sure you understand the daily dose (number of tablets each day) that your doctor has prescribed for you and follow the directions for treatment.

  • If you miss a dose, take it as soon as you remember on that day
  • If you forget to take STIVARGA until the next day, NEVER try to “catch up”—don’t take 2 doses on the same day to make up for a missed dose
  • Call your doctor/nurse or go to the nearest emergency room right away if you take more than your prescribed dose by mistake
Before starting STIVARGA
Blue caret
Storage of STIVARGA
Blue caret

What should I tell my doctor or nurse before taking STIVARGA?

Before taking STIVARGA, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems in addition to liver cancer
  • have bleeding problems
  • have high blood pressure
  • have heart problems or chest pain
  • plan to have surgery or have had recent surgery
  • are pregnant or plan to become pregnant. STIVARGA can harm your unborn baby. Females and males with female partners who can become pregnant should use effective birth control during treatment with STIVARGA and for 2 months after their last dose of STIVARGA. Tell your healthcare provider right away if you or your partner becomes pregnant either while taking STIVARGA or within 2 months after your last dose of STIVARGA
  • are breast-feeding or plan to breast-feed. It is not known if STIVARGA passes into your breast milk. Do not breastfeed during treatment with STIVARGA and for 2 weeks after your final dose of STIVARGA.

Tell your doctor or nurse about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. STIVARGA may affect the way other medicines work, and other medicines may affect how STIVARGA works.


Know Your Medicines

Know the medicines you take. Keep a list of your medicines and show it to your doctor or nurse and pharmacist when you get a new medicine.


Indications

STIVARGA® (regorafenib) is a prescription medicine used to treat people with:

It is not known if STIVARGA is safe and effective in children less than 18 years of age.

Important Safety Information

STIVARGA (regorafenib) can cause liver problems, which can be serious and sometimes lead to death. Your healthcare provider will do blood tests to check your liver function before you start taking STIVARGA and during your treatment with STIVARGA to check for liver problems. Tell your healthcare provider right away if you experience yellowing of your skin or the white part of your eyes, nausea, vomiting, dark urine, or change in your sleep pattern.

Before taking STIVARGA, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the prescription and over-the-counter medicines, vitamins, and herbal supplements you take. Avoid drinking grapefruit juice and taking St. John’s Wort while taking STIVARGA.

STIVARGA may cause serious side effects, including:

The most common side effects with STIVARGA include pain including stomach-area (abdomen); tiredness, weakness, fatigue; diarrhea (frequent or loose bowel movements); decreased appetite; infection; voice change or hoarseness; increase in certain liver function tests; fever; swelling, pain, and redness of the lining in your mouth, throat, stomach, and bowel (mucositis); and weight loss

For important risk and use information about STIVARGA, please see the full Prescribing Information, including Boxed Warning.

You are encouraged to report negative side effects or quality complaints of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.